Transfer of propafenone and 5-OH-propafenone to foetal plasma and maternal milk [letter]
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چکیده
منابع مشابه
A rapid and sensitive LC–MS/MS assay for the determination of propafenone and its active metabolite 5–hydroxy propafenone in human plasma using hybrid SPE precipitation technology
The quality of sample extraction had a significant impact on mass spectrometry results. The presence of phospholipids in the sample extracts resulted in poor quantitation and also it decreases the method robustness. Here we adopted a novel sample preparation Hybrid SPE phospholipid technology to extract plasma samples for improved phospholipid removal. This new method allowed simultaneous quant...
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Intoxication caused by propafenone is very rare, and there are no known detailed epidemiological studies. We present the clinical manifestation of severe propafenone intoxication,successfully treated in a 17 year-old male. He was brought to the Intensive Care Unit after he had taken 3.0 g propafenone. The main clinical findings included: sudden cardiac arrest, coma, hypotension, left ventricula...
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The objective of this randomized, double-blind, placebo-controlled clinical trial was to test the efficacy and safety of a new sustained-release preparation of the antiarrhythmic drug propafenone (propafenone SR) in reducing the frequency of symptomatic arrhythmia recurrences in patients with atrial fibrillation (AF). Patients with a history of symptomatic AF who were in sinus rhythm were rando...
متن کاملTHERAPY AND PREVENTION Clinical pharmacology of propafenone
We determined the efficacy, pharmacokinetics, and plasma concentration-response relationships ofpropafenone, a promising new antiarrhythmic drug. Thirteen patients with frequent and complex ventricular premature beats were studied after receiving four increasing doses, during drug washout and during a randomized double-blind placebo-controlled trial, to evaluate the optimal dose in each patient...
متن کاملSpectra of Propafenone and a Thiophene Analogue
Full and unambiguous asssignment of all Hand C-NMR resonances of the free bases as well as the hydrochloride salts of the antiarrhythmic agent propafenone and a thiophene analogue in different solutions (DMSO-d6, CDCl3) is reported.
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1991
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1991.tb03945.x